Fibrin(ogen)-Independent Role of Plasminogen Activators in Acetaminophen-Induced Liver Injury

Hepatic fibrin(ogen) has been noted to occur after acetaminophen (APAP)-induced liver injury in mice. Deficiency in plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor of fibrinolysis, increases APAP-induced liver injury in mice. However, the roles of fibrinogen and fibrinolysis in AP...

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Bibliografiske detaljer
Main Authors: Sullivan, Bradley P., Kassel, Karen M., Jone, Alice, Flick, Matthew J., Luyendyk, James P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2012
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378852/
https://ncbi.nlm.nih.gov/pubmed/22507835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.02.011
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