S-adenosylmethionine Regulates Ubiquitin-Conjugating Enzyme 9 Protein Expression and Sumoylation in Murine Liver and Human Cancers

BACKGROUND AND RATIONALE: Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and overexpressed in several malignancies but its expression in hepatocellular carcinoma (HCC) is unknown. Hepatic S-adenosylmethionine (SAMe) level falls in methionine adenosyltransferase 1A (Mat1a) knockout...

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Detalhes bibliográficos
Main Authors: Tomasi, Maria Lauda, Tomasi, Ivan, Ramani, Komal, Pascale, Rosa Maria, Xu, Jun, Giordano, Pasquale, Mato, José M., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378793/
https://ncbi.nlm.nih.gov/pubmed/22407595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25701
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