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INHIBITION OF NK CELLS PROTECTS THE LIVER AGAINST ACUTE INJURY IN THE ABSENCE OF GNMT
Glycine N-methyltransferase (GNMT) catabolizes S-adenosylmethionine (SAMe), the main methyl donor of the body. Patients with cirrhosis show attenuated GNMT expression, which is absent in HCC samples. GNMT(−/−) mice develop spontaneous steatosis that progresses to steatohepatitis, cirrhosis and HCC....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378767/ https://ncbi.nlm.nih.gov/pubmed/22392635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25694 |
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