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TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Glycine-N-methyltransferase (GNMT) is essential to preserve liver homeostasis. Thus, cirrhotic patients show low expression of GNMT that is absent in HCC samples. Accordingly, GNMT deficiency in mice leads to steatohepatitis, fibrosis, cirrhosis and HCC. Lack of GNMT triggers NK cell activation in G...
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| Veröffentlicht in: | Lab Invest |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310762/ https://ncbi.nlm.nih.gov/pubmed/25531568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.151 |
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