TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

Glycine-N-methyltransferase (GNMT) is essential to preserve liver homeostasis. Thus, cirrhotic patients show low expression of GNMT that is absent in HCC samples. Accordingly, GNMT deficiency in mice leads to steatohepatitis, fibrosis, cirrhosis and HCC. Lack of GNMT triggers NK cell activation in G...

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Detalhes bibliográficos
Publicado no:Lab Invest
Main Authors: Fernández-Álvarez, Sara, Juan, Virginia Gutiérrez-de, Zubiete-Franco, Imanol, Barbier-Torres, Lucia, Lahoz, Agustín, Parés, Albert, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C., Mato, José M., Martínez-Chantar, María Luz, Beraza, Naiara
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310762/
https://ncbi.nlm.nih.gov/pubmed/25531568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.151
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