TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

Glycine-N-methyltransferase (GNMT) is essential to preserve liver homeostasis. Thus, cirrhotic patients show low expression of GNMT that is absent in HCC samples. Accordingly, GNMT deficiency in mice leads to steatohepatitis, fibrosis, cirrhosis and HCC. Lack of GNMT triggers NK cell activation in G...

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Udgivet i:Lab Invest
Main Authors: Fernández-Álvarez, Sara, Juan, Virginia Gutiérrez-de, Zubiete-Franco, Imanol, Barbier-Torres, Lucia, Lahoz, Agustín, Parés, Albert, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C., Mato, José M., Martínez-Chantar, María Luz, Beraza, Naiara
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310762/
https://ncbi.nlm.nih.gov/pubmed/25531568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.151
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