Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

Mutations in the MSH2 gene predispose to a number of tumourigenic conditions, including hereditary non-polyposis colon cancer (HNPCC). MSH2 encodes a protein in the mismatch repair (MMR) pathway which is involved in the removal of mispairs originating during replication or from damaged DNA. To ident...

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Detalhes bibliográficos
Main Authors: Martin, Sarah A, McCarthy, Afshan, Barber, Louise J, Burgess, Darren J, Parry, Suzanne, Lord, Christopher J, Ashworth, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378145/
https://ncbi.nlm.nih.gov/pubmed/20049736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900040
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