Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

BACKGROUND: DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour. METHODS: To identify the therapeutic agents that might show selectivity for mismatch repair-deficient tumour cells, we screened a pair of...

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Autores principales: Hewish, M, Martin, S A, Elliott, R, Cunningham, D, Lord, C J, Ashworth, A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
Materias:
Genetics and Genomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590674/
https://ncbi.nlm.nih.gov/pubmed/23361057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.3
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