A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras

The c-Met receptor tyrosine kinase has been implicated in cellular transformation induced by mutant Ras, a commonly activated proto-oncogene in non-small cell lung cancer (NSCLC). However, the role of c-Met has not been defined in K-ras-mutant NSCLC, a disease for which no effective targeted therape...

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Autori principali: Yang, Yanan, Wislez, Marie, Fujimoto, Nobukazu, Prudkin, Ludmila, Izzo, Julie G., Uno, Futoshi, Ji, Lin, Hanna, Amy E., Langley, Robert R., Liu, Diane, Johnson, Faye M., Wistuba, Ignacio, Kurie, Jonathan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378059/
https://ncbi.nlm.nih.gov/pubmed/18413809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2045
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