PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

BACKGROUND: c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal embryogenesis, organogenesis, and tissue regeneration. Abnormal c-Met/HGF/SF signa...

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Hlavní autoři: Crosswell, Hal E, Dasgupta, Anindya, Alvarado, Carlos S, Watt, Tanya, Christensen, James G, De, Pradip, Durden, Donald L, Findley, Harry W
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790467/
https://ncbi.nlm.nih.gov/pubmed/19939254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-411
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