A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras

The c-Met receptor tyrosine kinase has been implicated in cellular transformation induced by mutant Ras, a commonly activated proto-oncogene in non-small cell lung cancer (NSCLC). However, the role of c-Met has not been defined in K-ras-mutant NSCLC, a disease for which no effective targeted therape...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Yang, Yanan, Wislez, Marie, Fujimoto, Nobukazu, Prudkin, Ludmila, Izzo, Julie G., Uno, Futoshi, Ji, Lin, Hanna, Amy E., Langley, Robert R., Liu, Diane, Johnson, Faye M., Wistuba, Ignacio, Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378059/
https://ncbi.nlm.nih.gov/pubmed/18413809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2045
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados