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Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition

PURPOSE: The receptor tyrosine kinase (RTK) c-MET and its ligand hepatocyte growth factor (HGF) are deregulated and promote malignancy in cancer and brain tumors. Consequently, clinically applicable c-MET inhibitors have been developed. The purpose of this study was to investigate the not well known...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Ying, Farenholtz, Kaitlyn E., Yang, Yanzhi, Guessous, Fadila, diPierro, Charles G., Calvert, Valerie S., Deng, Jianghong, Schiff, David, Xin, Wenjun, Lee, Jae K., Purow, Benjamin, Christensen, James, Petricoin, Emanuel, Abounader, Roger
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602223/
https://ncbi.nlm.nih.gov/pubmed/23386689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2832
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