The OPCML Tumor Suppressor Functions as a Cell Surface Repressor-Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy and its molecular basis is poorly understood. We previously showed that OPCML was frequently epigenetically inactivated in EOC, with suppressor function in-vitro and in-vivo. Here, we further show the clinical...

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Main Authors: McKie, Arthur B., Vaughan, Sebastian, Zanini, Elisa, Okon, Imoh S., Louis, Louay, de Sousa, Camila, Greene, Mark I., Wang, Qiang, Agarwal, Roshan, Shaposhnikov, Dmitry, Wong, Joshua LC, Gungor, Hatice, Janczar, Szymon, El-Bahrawy, Mona, Lam, Eric W-F, Chayen, Naomi E., Gabra, Hani
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378039/
https://ncbi.nlm.nih.gov/pubmed/22585860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0256
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