The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer

In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI‐anchored tumour suppressor OPCML. Further, we demonstrate that AXL directly interacts with OPCML...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Rep
Prif Awduron: Antony, Jane, Zanini, Elisa, Kelly, Zoe, Tan, Tuan Zea, Karali, Evdoxia, Alomary, Mohammad, Jung, Youngrock, Nixon, Katherine, Cunnea, Paula, Fotopoulou, Christina, Paterson, Andrew, Roy‐Nawathe, Sushmita, Mills, Gordon B, Huang, Ruby Yun‐Ju, Thiery, Jean Paul, Gabra, Hani, Recchi, Chiara
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073217/
https://ncbi.nlm.nih.gov/pubmed/29907679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745670
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