The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer

In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI‐anchored tumour suppressor OPCML. Further, we demonstrate that AXL directly interacts with OPCML...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EMBO Rep
Κύριοι συγγραφείς: Antony, Jane, Zanini, Elisa, Kelly, Zoe, Tan, Tuan Zea, Karali, Evdoxia, Alomary, Mohammad, Jung, Youngrock, Nixon, Katherine, Cunnea, Paula, Fotopoulou, Christina, Paterson, Andrew, Roy‐Nawathe, Sushmita, Mills, Gordon B, Huang, Ruby Yun‐Ju, Thiery, Jean Paul, Gabra, Hani, Recchi, Chiara
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2018
Θέματα:
Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073217/
https://ncbi.nlm.nih.gov/pubmed/29907679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745670
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