Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Long-term exposure to ascorbate is known to enhance endothelial nitric oxide synthase (eNOS) activity by stabilizing the eNOS cofactor tetrahydrobiopterin (BH4). We investigated acute effects of ascorbate on eNOS function in primary (HUVEC) and immortalized human endothelial cells (EA.hy926), aiming...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ladurner, Angela, Schmitt, Christoph A., Schachner, Daniel, Atanasov, Atanas G., Werner, Ernst R., Dirsch, Verena M., Heiss, Elke H.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science 2012
Sujets:
Original Contribution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377995/
https://ncbi.nlm.nih.gov/pubmed/22542797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.03.022
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