Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Long-term exposure to ascorbate is known to enhance endothelial nitric oxide synthase (eNOS) activity by stabilizing the eNOS cofactor tetrahydrobiopterin (BH4). We investigated acute effects of ascorbate on eNOS function in primary (HUVEC) and immortalized human endothelial cells (EA.hy926), aiming...

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Detalhes bibliográficos
Main Authors: Ladurner, Angela, Schmitt, Christoph A., Schachner, Daniel, Atanasov, Atanas G., Werner, Ernst R., Dirsch, Verena M., Heiss, Elke H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2012
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Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377995/
https://ncbi.nlm.nih.gov/pubmed/22542797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.03.022
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