Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Long-term exposure to ascorbate is known to enhance endothelial nitric oxide synthase (eNOS) activity by stabilizing the eNOS cofactor tetrahydrobiopterin (BH4). We investigated acute effects of ascorbate on eNOS function in primary (HUVEC) and immortalized human endothelial cells (EA.hy926), aiming...

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Bibliografische gegevens
Hoofdauteurs: Ladurner, Angela, Schmitt, Christoph A., Schachner, Daniel, Atanasov, Atanas G., Werner, Ernst R., Dirsch, Verena M., Heiss, Elke H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Science 2012
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Original Contribution
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377995/
https://ncbi.nlm.nih.gov/pubmed/22542797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.03.022
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