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Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

[Image: see text] The C-19 quassinoid eurycomalactone (1) has recently been shown to be a potent (IC(50) = 0.5 μM) NF-κB inhibitor in a luciferase reporter model. In this study, we show that 1 with similar potency inhibited the expression of the NF-κB-dependent target genes ICAM-1, VCAM-1, and E-sel...

詳細記述

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書誌詳細
出版年:J Nat Prod
主要な著者: Malainer, Clemens, Schachner, Daniel, Sangiovanni, Enrico, Atanasov, Atanas G., Schwaiger, Stefan, Stuppner, Hermann, Heiss, Elke H., Dirsch, Verena M.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society and American Society of Pharmacognosy 2017
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744186/
https://ncbi.nlm.nih.gov/pubmed/29148754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.7b00503
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