Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

The cellular recognition of viruses evokes the secretion of type-I interferons (IFNs) that induce an antiviral protective state. By live-cell imaging, we show that key steps of virus-induced signal transduction, IFN-β expression, and induction of IFN-stimulated genes (ISGs) are stochastic events in...

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Détails bibliographiques
Auteurs principaux: Rand, Ulfert, Rinas, Melanie, Schwerk, Johannes, Nöhren, Gesa, Linnes, Melanie, Kröger, Andrea, Flossdorf, Michael, Kály-Kullai, Kristóf, Hauser, Hansjörg, Höfer, Thomas, Köster, Mario
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377992/
https://ncbi.nlm.nih.gov/pubmed/22617958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.17
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