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Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response
The cellular recognition of viruses evokes the secretion of type-I interferons (IFNs) that induce an antiviral protective state. By live-cell imaging, we show that key steps of virus-induced signal transduction, IFN-β expression, and induction of IFN-stimulated genes (ISGs) are stochastic events in...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377992/ https://ncbi.nlm.nih.gov/pubmed/22617958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.17 |
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