Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse hepatitis virus (MHV), causes acute hepatitis in its natural host and provides a useful model for understanding virus interaction wit...

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Detalhes bibliográficos
Main Authors: Zhao, Ling, Jha, Babal K., Wu, Ashley, Elliott, Ruth, Ziebuhr, John, Gorbalenya, Alexander E., Silverman, Robert H., Weiss, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377938/
https://ncbi.nlm.nih.gov/pubmed/22704621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.04.011
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