O030 Evasion of the OAS-RNase L pathway by murine coronavirus ns2 protein is required for viral replication and hepatitis

INTRODUCTION: The 2′,5′-oligoadenylate synthetase-ribonuclease L (OAS-RNase L) system is a potent IFN induced antiviral pathway. Following infection, IFNs induce a group of OAS genes whose products are activated by viral double-stranded RNA. OAS uses ATP to generate 2′,5′-linked oligoadenylates (2-5...

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Udgivet i:Cytokine
Main Authors: Jha, B.K., Zhao, L., Wu, A., Elliot, R., Ziebuhr, J., Gorbalenya, A.E., Weiss, S.R., Silverman, R.H.
Format: Artigo
Sprog:Inglês
Udgivet: Published by Elsevier Ltd. 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7130074/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2012.06.064
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