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FOXO3: A master switch for regulating tolerance and immunity in dendritic cells

Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potenti...

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Bibliografske podrobnosti
Main Authors: Watkins, Stephanie K., Hurwitz, Arthur A.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376981/
https://ncbi.nlm.nih.gov/pubmed/22720261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.2.18241
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