Foxo3 controls the magnitude of T cell immune responses by modulating dendritic cell function

Foxo transcription factors regulate cell cycle progression, survival, and DNA repair pathways. Here, we demonstrate that a deficiency in Foxo3 resulted in increased expansion of T cell populations after viral infection. This exaggerated expansion was not T cell intrinsic. Rather, it was caused by th...

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Autori principali: Dejean, Anne S., Beisner, Daniel R., Ch’en, Irene L., Kerdiles, Yann M., Babour, Anna, Arden, Karen C., Castrillon, Diego H., DePinho, Ronald A., Hedrick, Stephen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712214/
https://ncbi.nlm.nih.gov/pubmed/19363483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1729
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