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Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and m...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376956/ https://ncbi.nlm.nih.gov/pubmed/22720223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.1.17930 |
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