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Target-Mediated Disposition Model Describing the Dynamics of IL12 and IFNγ after Administration of a Mifepristone-Inducible Adenoviral Vector for IL-12 Expression in Mice

Interleukin-12 (IL12) is a cytokine with potential applications in the treatment of cancer given the potent immune response that it triggers, in part due to its ability to stimulate expression of interferon-γ (IFNγ). To avoid the toxicity associated with systemic exposure to IL12, a high-capacity ad...

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Dettagli Bibliografici
Autori principali: Parra-Guillen, Zinnia Patricia, Janda, Alvaro, Alzuguren, Pilar, Berraondo, Pedro, Hernandez-Alcoceba, Ruben, Troconiz, Iñaki F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535095/
https://ncbi.nlm.nih.gov/pubmed/23135926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9423-9
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