Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

Coordinated release of calcium (Ca(2+)) from the sarcoplasmic reticulum (SR) through cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited disease characterized by stress-induced ventricular a...

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Autors principals: Jung, Christian B, Moretti, Alessandra, Mederos y Schnitzler, Michael, Iop, Laura, Storch, Ursula, Bellin, Milena, Dorn, Tatjana, Ruppenthal, Sandra, Pfeiffer, Sarah, Goedel, Alexander, Dirschinger, Ralf J, Seyfarth, Melchior, Lam, Jason T, Sinnecker, Daniel, Gudermann, Thomas, Lipp, Peter, Laugwitz, Karl-Ludwig
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376852/
https://ncbi.nlm.nih.gov/pubmed/22174035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100194
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