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Dantrolene prevents arrhythmogenic Ca(2+) release in heart failure
In heart failure (HF), arrhythmogenic Ca(2+) release and chronic Ca(2+) depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR Ca(2+)-release channel. Dantrolene, a therapeutic agent used to treat malignant hyperthermia associated with mutations...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322737/ https://ncbi.nlm.nih.gov/pubmed/22180651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00936.2011 |
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