A Reversible Early Oxidized Redox State That Precedes Macromolecular ROS Damage in Aging Nontransgenic and 3xTg-AD Mouse Neurons

The brain depends on redox electrons from nicotinamide adenine dinucleotide (reduced form; NADH) to produce ATP and oxyradicals (reactive oxygen species [ROS]). Because ROS damage and mitochondrial dysregulation are prominent in aging and Alzheimer's disease (AD) and their relationship to the r...

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Main Authors: Ghosh, Debolina, LeVault, Kelsey R., Barnett, Aaron J., Brewer, Gregory J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376759/
https://ncbi.nlm.nih.gov/pubmed/22539844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6192-11.2012
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