Staphylococcus aureus FabI: Inhibition, Substrate Recognition and Potential Implications for In Vivo Essentiality

Methicillin-resistant Staphylococcus aureus (MRSA) infections constitute a serious health threat worldwide, and novel antibiotics are therefore urgently needed. The enoyl-ACP reductase (saFabI) is essential for the S. aureus fatty acid biosynthesis and, hence, serves as an attractive drug target. We...

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Autores principales: Schiebel, Johannes, Chang, Andrew, Lu, Hao, Baxter, Michael V., Tonge, Peter J., Kisker, Caroline
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376755/
https://ncbi.nlm.nih.gov/pubmed/22579249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.03.013
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