Estradiol induces cytochrome P450 2B6 expression at high concentrations: Implication in estrogen-mediated gene regulation in pregnancy

Pregnancy alters the rate and extent of drug metabolism, but little is known about the underlying molecular mechanism. We have found that 17β-estradiol (E2) upregulates expression of the major drug-metabolizing enzyme CYP2B6 in primary human hepatocytes. Results from promoter reporter assays in HepG...

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Библиографические подробности
Главные авторы: Koh, Kwi Hye, Jurkovic, Steve, Yang, Kyunghee, Choi, Su-Young, Jung, Jin Woo, Kim, Kwang Pyo, Zhang, Wei, Jeong, Hyunyoung
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376749/
https://ncbi.nlm.nih.gov/pubmed/22484313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.016
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