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Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats
Estradiol (E2) is the major endogenous estrogen, and its plasma concentration increases up to 100-fold during pregnancy in humans. Accumulating evidence suggests that an elevated level of E2 may influence hepatic drug metabolism, potentially being responsible for altered drug metabolism during pregn...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061489/ https://ncbi.nlm.nih.gov/pubmed/21219883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.12.019 |
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