Development of (99m)Tc-N4-NIM for Molecular Imaging of Tumor Hypoxia

The nitro group of 2-nitroimidazole (NIM) enters the tumor cells and is bioreductively activated and fixed in the hypoxia cells. 1,4,8,11-tetraazacyclotetradecane (N4) has shown to be a stable chelator for (99m)Tc. The present study was aimed to develop (99m)Tc-cyclam-2-nitroimidazole ((99m)Tc-N4-NI...

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Autores principales: Ali, Mohammad S., Kong, Fan-Lin, Rollo, Alex, Mendez, Richard, Kohanim, Saady, Smith, Daniel Lee, Yang, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376529/
https://ncbi.nlm.nih.gov/pubmed/22719210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/828139
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