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Development of (99m)Tc-N4-NIM for Molecular Imaging of Tumor Hypoxia
The nitro group of 2-nitroimidazole (NIM) enters the tumor cells and is bioreductively activated and fixed in the hypoxia cells. 1,4,8,11-tetraazacyclotetradecane (N4) has shown to be a stable chelator for (99m)Tc. The present study was aimed to develop (99m)Tc-cyclam-2-nitroimidazole ((99m)Tc-N4-NI...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376529/ https://ncbi.nlm.nih.gov/pubmed/22719210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/828139 |
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