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Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
Human cancers with a subtetraploid karyotype are thought to originate from tetraploid precursors, but the cause of tetraploidization is unknown. We previously documented endoreduplication in mouse cells with persistent telomere dysfunction or genome-wide DNA damage. We now report that endoreduplicat...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376354/ https://ncbi.nlm.nih.gov/pubmed/22698402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.044 |
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