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Different telomere damage signaling pathways in human and mouse cells
Programmed telomere shortening in human somatic cells is thought to act as a tumor suppressor pathway, limiting the replicative potential of developing tumor cells. Critically short human telomeres induce senescence either by activating p53 or by inducing the p16/RB pathway, and suppression of both...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2002
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126171/ https://ncbi.nlm.nih.gov/pubmed/12169636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf433 |
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