Quantitative Nano-Scale Analysis of IgE-FcεRI Clustering and Coupling to Early Signaling Proteins

Antigen-mediated crosslinking of IgE bound to its receptor, FcεRI, initiates a transmembrane signaling cascade that results in mast cell activation in the allergic response. Using immunogold labeling of intact RBL mast cells and scanning electron microscopy (SEM), we visualize molecular reorganizati...

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Bibliographic Details
Main Authors: Veatch, Sarah L., Chiang, Ethan N., Sengupta, Prabuddha, Holowka, David A., Baird, Barbara A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376227/
https://ncbi.nlm.nih.gov/pubmed/22397623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp300197p
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