The structural basis for substrate versatility of chloramphenicol acetyltransferase CAT(I)

Novel antibiotics are needed to overcome the challenge of continually evolving bacterial resistance. This has led to a renewed interest in mechanistic studies of once popular antibiotics like chloramphenicol (CAM). Chloramphenicol acetyltransferases (CATs) are enzymes that covalently modify CAM, ren...

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Bibliographic Details
Main Authors: Biswas, Tapan, Houghton, Jacob L, Garneau-Tsodikova, Sylvie, Tsodikov, Oleg V
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375752/
https://ncbi.nlm.nih.gov/pubmed/22294317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2036
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