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Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis
During the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. A direct and fast activation of caspase-8 by cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis. Nevertheless, the activation mechanism of caspase-8 remains unclear. Here, by using s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375537/ https://ncbi.nlm.nih.gov/pubmed/22528489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306399 |
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