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Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
In the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. We describe a new proapoptotic pathway in which cathepsin D directly activates caspase-8. Cathepsin D is released from azurophilic granules in neutrophils in a caspase-independent but reactive oxygen species–dependen...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275389/ https://ncbi.nlm.nih.gov/pubmed/18299403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072152 |
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