Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis

In polymyositis and inclusion body myositis, muscle fibers are surrounded and invaded by CD8-positive cytotoxic T cells expressing the αβ-T cell receptor (αβ-TCR) for antigen. In a rare variant of myositis, muscle fibers are similarly attacked by CD8-negative T cells expressing the γδ-TCR (γδ-T cell...

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Bibliographische Detailangaben
Hauptverfasser: Bruder, Jessica, Siewert, Katherina, Obermeier, Birgit, Malotka, Joachim, Scheinert, Peter, Kellermann, Josef, Ueda, Takuya, Hohlfeld, Reinhard, Dornmair, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375522/
https://ncbi.nlm.nih.gov/pubmed/22549773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356709
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