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Taurine Inhibits K(+)-Cl(−) Cotransporter KCC2 to Regulate Embryonic Cl(−) Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway
GABA inhibits mature neurons and conversely excites immature neurons due to lower K(+)-Cl(−) cotransporter 2 (KCC2) expression. We observed that ectopically expressed KCC2 in embryonic cerebral cortices was not active; however, KCC2 functioned in newborns. In vitro studies revealed that taurine incr...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375508/ https://ncbi.nlm.nih.gov/pubmed/22544747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319418 |
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