Taurine Inhibits K(+)-Cl(−) Cotransporter KCC2 to Regulate Embryonic Cl(−) Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

GABA inhibits mature neurons and conversely excites immature neurons due to lower K(+)-Cl(−) cotransporter 2 (KCC2) expression. We observed that ectopically expressed KCC2 in embryonic cerebral cortices was not active; however, KCC2 functioned in newborns. In vitro studies revealed that taurine incr...

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Bibliographic Details
Main Authors: Inoue, Koichi, Furukawa, Tomonori, Kumada, Tatsuro, Yamada, Junko, Wang, Tianying, Inoue, Rieko, Fukuda, Atsuo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375508/
https://ncbi.nlm.nih.gov/pubmed/22544747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319418
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