Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine

8-Oxo-7,8-dihydroguanine (8-oxoG), arguably the most abundant base lesion induced in mammalian genomes by reactive oxygen species, is repaired via the base excision repair pathway that is initiated with the excision of 8-oxoG by OGG1. Here we show that OGG1 binds the 8-oxoG base with high affinity a...

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Main Authors: Boldogh, Istvan, Hajas, Gyorgy, Aguilera-Aguirre, Leopoldo, Hegde, Muralidhar L., Radak, Zsolt, Bacsi, Attila, Sur, Sanjiv, Hazra, Tapas K., Mitra, Sankar
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375501/
https://ncbi.nlm.nih.gov/pubmed/22568941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.364620
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