8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

8-Oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant DNA base lesions induced by reactive oxygen species (ROS). Accumulation of 8-oxoG in the mammalian genome is considered a marker of oxidative stress, to be causally linked to inflammation, and is thought to contribute to aging processes a...

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Main Authors: Hajas, Gyorgy, Bacsi, Attila, Aguilera-Aguirre, Leopoldo, Hegde, Muralidhar L., Tapas, K. Hazra, Sur, Sanjiv, Radak, Zsolt, Ba, Xueqing, Boldogh, Istvan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795866/
https://ncbi.nlm.nih.gov/pubmed/23612479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.011
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