Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

To reduce damage from toxic insults such as glutamate excitotoxicity and oxidative stresses, neurons may deploy an array of neuroprotective mechanisms. Recent reports show that progranulin (PGRN) gene null or missense mutations leading to inactive protein, are linked to frontotemporal lobar degenera...

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Bibliografiska uppgifter
Huvudupphovsmän: Xu, Jindong, Xilouri, Maria, Bruban, Julien, Shioi, Junichi, Shao, Zhiping, Papazoglou, Ioannis, Vekrellis, Kostas, Robakis, Nikolaos K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375317/
https://ncbi.nlm.nih.gov/pubmed/21820214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.06.017
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