Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation

Engineering novel allostery into existing proteins is a challenging endeavor to obtain novel sensors, therapeutic proteins, or modulate metabolic and cellular processes. The RG13 protein achieves such allostery by inserting a circularly permuted TEM-1 β-lactamase gene into the maltose binding protei...

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Detalhes bibliográficos
Main Authors: Ke, Wei, Laurent, Abigail H., Armstrong, Morgan D., Chen, Yuchao, Smith, William E., Liang, Jing, Wright, Chapman M., Ostermeier, Marc, van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375305/
https://ncbi.nlm.nih.gov/pubmed/22720063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039168
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