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Designing heterotropically activated allosteric conformational switches using supercharging
Heterotropic allosteric activation of protein function, in which binding of one ligand thermodynamically activates the binding of another, different ligand or substrate, is a fundamental control mechanism in metabolism and as such has been a long-aspired capability in protein design. Here we show th...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7071918/ https://ncbi.nlm.nih.gov/pubmed/32098845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916046117 |
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