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DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition

Group A Streptococcus (GAS) has developed a broad arsenal of virulence factors that serve to circumvent host defense mechanisms. The virulence factor DNase Sda1 of the hyperinvasive M1T1 GAS clone degrades DNA-based neutrophil extracellular traps allowing GAS to escape extracellular killing. TLR9 is...

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Autors principals: Uchiyama, Satoshi, Andreoni, Federica, Schuepbach, Reto A., Nizet, Victor, Zinkernagel, Annelies S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375267/
https://ncbi.nlm.nih.gov/pubmed/22719247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002736
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