Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding

BACKGROUND: Recombinant gp120 (MN-rgp120) was a major component of the AIDSVAX B/E vaccine used in the RV144 trial. This was the first clinical trial to show that vaccination could prevent HIV infection in humans. A recent RV144 correlates of protection study found that protection correlated with th...

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Main Authors: Nakamura, Gerald R., Fonseca, Dora P. A. J., O'Rourke, Sara M., Vollrath, Aaron L., Berman, Phillip W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374778/
https://ncbi.nlm.nih.gov/pubmed/22720026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039045
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