ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease

Aberrant chromatin remodeling is involved in the pathogenesis of Huntington's disease (HD) but the mechanism is not known. Herein, we report that mutant huntingtin (mtHtt) induces the transcription of alpha thalassemia/mental retardation X linked (ATRX), an ATPase/helicase and SWI/SNF-like chro...

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書誌詳細
主要な著者: Lee, J, Hong, Y K, Jeon, G S, Hwang, Y J, Kim, K Y, Seong, K H, Jung, M-K, Picketts, D J, Kowall, N W, Cho, K S, Ryu, H
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
Original Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374076/
https://ncbi.nlm.nih.gov/pubmed/22240898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.196
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