Immunogenicity of DNA Vaccines Encoding Simian Immunodeficiency Virus Antigen Targeted to Dendritic Cells in Rhesus Macaques

BACKGROUND: Targeting antigens encoded by DNA vaccines to dendritic cells (DCs) in the presence of adjuvants enhances their immunogenicity and efficacy in mice. METHODOLOGY/PRINCIPAL FINDINGS: To explore the immunogenicity of this approach in non-human primates, we generated a single chain antibody...

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Hlavní autoři: Tenbusch, Matthias, Ignatius, Ralf, Nchinda, Godwin, Trumpfheller, Christine, Salazar, Andres M., Töpfer, Katharina, Sauermann, Ulrike, Wagner, Ralf, Hannaman, Drew, Tenner-Racz, Klara, Racz, Paul, Stahl-Hennig, Christiane, Überla, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373620/
https://ncbi.nlm.nih.gov/pubmed/22720025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039038
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