Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular recepto...

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Autores principales: Stahl-Hennig, Christiane, Eisenblätter, Martin, Jasny, Edith, Rzehak, Tamara, Tenner-Racz, Klara, Trumpfheller, Christine, Salazar, Andres M., Überla, Klaus, Nieto, Karen, Kleinschmidt, Jürgen, Schulte, Reiner, Gissmann, Lutz, Müller, Martin, Sacher, Anna, Racz, Paul, Steinman, Ralph M., Uguccioni, Mariagrazia, Ignatius, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660151/
https://ncbi.nlm.nih.gov/pubmed/19360120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000373
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